What should be avoided when applying CHG near mucous membranes?

• A. CHG should be avoided near mucous membranes or open wounds
• B. Povidone-iodine is always preferred on mucous membranes
• C. Antiseptics should not contact skin
• D. CHG is safe on all mucous membranes

Answer: (A)

Avoid applying CHG near mucous membranes because these tissues are more sensitive and more permeable than intact skin. When CHG contacts mucous membranes or open wounds, it can cause chemical irritation or injury and may be absorbed, leading to local damage or systemic effects. For that reason, CHG should be kept away from mucous membranes; if mucosal antisepsis is needed, an alternative agent (such as povidone-iodine) is typically considered. The idea that CHG is safe on all mucous membranes or that antiseptics should not contact skin aren’t correct, and saying povidone-iodine is always preferred is not universally true.